University of North Carolina, Chapel Hill

Ph.D. in Epidemiology

Chapel Hill, NC

2018 - 2013

Thesis: Infant growth trajectories and lipid levels in adolescence

University of Pennsylvania

M.A. in Demography

Philadelphia, PA

2005

University of North Carolina, Chapel Hill

M.S. in Biostatistics

Chapel Hill, NC

2003

Johns Hopkins University

M.H.S. in Population Dynamics

Baltimore, MD

1995

University of California, San Diego

B.A. in Applied Math

San Diego, CA

1993

National Institute of Environmental Health Sciences

Postdoctoral Fellow, Advisor: Clarice R. Weinberg

Research Triangle Park, NC

2018 - present

• Research topics: Familial risk and biomarkers associated with breast cancer incidence
• Investigating the role of serum iron biomarkers in breast cancer incidence
• Applied survival analysis and data visualization to develop new method to estimate familial aggregation of breast cancer age of onset
• Developed analysis plans to synthesize a priori approach to projects

University of North Carolina, Department of Epidemiology

Graduate Researcher, Advisor: Kari E. North

Chapel Hill, NC

2013 - 2018

• Research topics: Infant anthropometric growth as 1) a factor associated with sociodemographic risk factors, 2) an exposure hypothesized to modify lipid levels in adolescence and 3) an effect modifier of the association between genetic risk variants and lipid levels.
• Estimated different patterns of infant growth and their association with lipid levels in adolescence with structural equation models, factor analysis, and non-linear random effects models.
• Documented all work with reproducible reports written in R, markdown and LaTeX; tracked script development with Git.

University of North Carolina, Center of Excellence for Eating Disorders (CEED)

Biostatistician

Chapel Hill, NC

2005 - 2013

• Collaborated in the planning and interpretation of statistical analyses for research papers authored by faculty, post-doctoral fellows, graduate students and undergraduate students.
• Analyzed data with regression and structural equation models in SAS and R.
• Participated in manuscript writing process, which included the statistical methods sections, data visualizations and overall data integrity.

Maryland Healthcare Commission

Research analyst

Baltimore, MD

1999 - 2000

• Assisted in the planning and production of analyses regarding the status of the uninsured in Maryland with federal survey data.

Peace Corps

Public Health Specialist

Togo, Africa

1997 - 1998

Individual Predoctoral Fellowship Award (Award: 16PRE29200008)

American Heart Association

N/A

2016-2018

Summer travel scholarship award

Summer Institute in Statistical Genetics

Seattle, WA

2014-2016

Ruth L. Kirschstein Pre-Doctoral Institutional National Research Service Award

National Institute of Child Health and Development, National Institutes of Health

N/A

2001-2005

Oral presentations

N/A

N/A

N/A

• Von Holle A, North KE, Gahagan S, Blanco, E, et al. Infant Growth Trajectories and Lipid Levels in Adolescence: Evidence from a Chilean Infancy Cohort. Oral presentation at American Heart Association EPI/Lifestyle; 2018; New Orleans, Louisiana.
• Von Holle A, Thornton L, Kaye W, Bulik C. Conditional Probability and Rate of Remission of Eating Disorders. Oral presentation at: International Conference of Eating Disorders; 2007; Baltimore, Maryland.
• Von Holle A Associations between Partner-Based Childcare and Fertility of Married Working Mothers. Refereed roundtable presentation at: Annual meeting of the American Sociological Association; 2006; Montreal, Canada.
• Von Holle A, Suchindran C. Data depth and infant mortality differentials. Oral presentation at: Eastern North American Region of the International Biometric Society (ENAR); 2003; Tampa, Florida.

Poster presentations

N/A

N/A

N/A

• Von Holle A, O’Brien K, Sandler DP, Weinberg CR. Familial aggregation of age of onset for breast cancer risk. Poster presented at the Society of Epidemiological Research annual meeting; 2019; Minneapolis, MD.
• Von Holle A, North KE, Gahagan S, Blanco E, et al. Sociodemographic predictors of early postnatal growth. Poster presented at the Society of Epidemiological Research annual meeting; 2018; Baltimore, MD.
• Von Holle A, North KE, Gahagan S, Blanco E, et al. Infant Growth As An Effect Modifier Of Genetic-Lipid Associations: Evidence From A Chilean Infancy Cohort. Poster presented at the American Heart Association EPI/Lifestyle annual meeting; 2018; New Orleans, Louisiana.
• Von Holle A, North KE. Confirmatory factor analysis (CFA) of multivariate lipid distributions across time and race-ethnic groups: United States, 2003-2012. Poster presented at the American Heart Association EPI/Lifestyle annual meeting; 2017; Portland, Oregon.
• Von Holle A, Justice, A, North KE, et al. Lipid-related Genetic Variants and Lipid Outcomes in a Cohort of Chilean Children. Poster presented at the American Heart Association EPI/Lifestyle annual meeting; 2017; Portland, Oregon.
• Von Holle A, North KE, Gahagan S, Tao R. The utility of standardized or crude weight measures in modeling of postnatal growth trajectories: Are there differences? Poster presented at the 2016 Epidemiology Congress of the Americas, Miami, Florida.
• Von Holle A, North KE, Kang E, Blanco E, Gahagan S. Childhood BMI Associated with Low HDL-C Levels in Adolescence in a Chilean Cohort. Poster presented at the American Heart Association EPI/Lifestyle annual meeting; 2015; Baltimore, Maryland.
• Von Holle A, U.S. Women’s Labor Force Participation, Children and Change: 1980-2000. Poster presented at the Population Association of America annual meeting; 2005; Philadelphia, Pennsylvania.
• Von Holle A, Suchindran C. A Non-Parametric Application for Exploratory Multivariate Data Analysis Using Infant Mortality Rates. Poster presented at the Population Association of America annual meeting; 2004; Boston, Massachusetts.

Publications

N/A

N/A

N/A

• Von Holle A, North KE, Gahagan S, et al. Infant Growth Trajectories and Lipid Levels in Adolescence: Evidence from a Chilean Infancy Cohort. American Journal of Epidemiology. 2021; In press.
• Viera, A. J., Yano, Y., Lin, F.-C., Simel, D. L., Yun, J., Dave, G., Von Holle, A., Viera, L. A., Shimbo, D., Hardy, S. T., Donahue, K. E., Hinderliter, A., Voisin, C. E., & Jonas, D. E. (2021). Does This Adult Patient Have Hypertension?: The Rational Clinical Examination Systematic Review. JAMA, 326(4), 339–347. doi: 10.1001/jama.2021.4533
• Von Holle A, O’Brien KM, Sandler DP, Janicek R, Weinberg CR. Association Between Serum Iron Biomarkers and Breast Cancer. Cancer Epidemiol Biomarkers Prev. 2021;30(2):422-425. doi:10.1158/1055-9965.EPI-20-0715
• Von Holle A, O’Brien KM, Sandler DP, Weinberg CR. Familial clustering in breast cancer age of onset. International Journal of Epidemiology. 2020. doi:10.1093/ije/dyaa201
• Von Holle A, North KE, Gahagan S, et al. Sociodemographic predictors of early postnatal growth: evidence from a Chilean infancy cohort. BMJ OPEN. 2020;10(6). doi:10.1136/bmjopen-2019-033695
• Von Holle A, North KE, Tao R, Gahagan S. The perils of standardizing infant weight to assess weight change differences across exposure groups. ANNALS OF EPIDEMIOLOGY. 2018;28(8):515-520. doi:10.1016/j.annepidem.2018.04.006
• Watson HJ, Von Holle A, Knoph C, et al. Psychosocial factors associated with bulimia nervosa during pregnancy: An internal validation study. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2015;48(6):654-662. doi:10.1002/eat.22361
• Peat CM, Von Holle A, Watson H, et al. The association between internet and television access and disordered eating in a Chinese sample. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2015;48(6):663-669. doi:10.1002/eat.22359
• Perrin EM, Von Holle A, Zerwas S, et al. Weight-for-length trajectories in the first year of life in children of mothers with eating disorders in a large norwegian cohort. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2015;48(4):406-414. doi:10.1002/eat.22290
• Abebe DS, Von Soest T, Von Holle A, Zerwas SC, Torgersen L, Bulik CM. Developmental trajectories of postpartum weight 3 years after birth: Norwegian mother and child cohort study. MATERNAL AND CHILD HEALTH JOURNAL. 2015;19(4):917-925. doi:10.1007/s10995-014-1593-x
• Zerwas S, Von Holle A, Watson H, Gottfredson N, Bulik CM. Childhood anxiety trajectories and adolescent disordered eating: Findings from the NICHD study of early child care and youth development. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2014;47(7, SI):784-792. doi:10.1002/eat.22318
• Zerwas SC, Von Holle A, Perrin EM, et al. Gestational and postpartum weight change patterns in mothers with eating disorders. EUROPEAN EATING DISORDERS REVIEW. 2014;22(6):397-404. doi:10.1002/erv.2314
• Runfola CD, Zucker NL, Von Holle A, et al. NURTURE: Development and pilot testing of a novel parenting intervention for mothers with histories of an eating disorder. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2014;47(1):1-12. doi:10.1002/eat.22178
• Algars M, Huang L, Von Holle AF, et al. Binge eating and menstrual dysfunction. JOURNAL OF PSYCHOSOMATIC RESEARCH. 2014;76(1):19-22. doi:10.1016/j.jpsychores.2013.11.011
• Peat CM, Huang L, Thornton LM, et al. Binge eating, body mass index, and gastrointestinal symptoms. JOURNAL OF PSYCHOSOMATIC RESEARCH. 2013;75(5):456-461. doi:10.1016/j.jpsychores.2013.08.009
• Runfola CD, Von Holle A, Peat CM, et al. Characteristics of women with body size satisfaction at midlife: Results of the gender and body image (GABI) study. JOURNAL OF WOMEN & AGING. 2013;25(4):287-304. doi:10.1080/08952841.2013.816215
• Watson HJ, Von Holle A, Hamer RM, et al. Remission, continuation and incidence of eating disorders during early pregnancy: a validation study in a population-based birth cohort. PSYCHOLOGICAL MEDICINE. 2013;43(8):1723-1734. doi:10.1017/S0033291712002516
• Zerwas S, Lund BC, Von Holle A, et al. Factors associated with recovery from anorexia nervosa. JOURNAL OF PSYCHIATRIC RESEARCH. 2013;47(7):972-979. doi:10.1016/j.jpsychires.2013.02.011
• Brownley KA, Von Holle A, Hamer RM, La Via M, Bulik CM. A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: Results of the Binge Eating and Chromium (BEACh) Study. JOURNAL OF PSYCHOSOMATIC RESEARCH. 2013;75(1):36-42. doi:10.1016/j.jpsychores.2013.03.092
• Knoph C, Von Holle A, Zerwas S, et al. Course and predictors of maternal eating disorders in the postpartum period. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2013;46(4):355-368. doi:10.1002/eat.22088
• Runfola CD, Von Holle A, Trace SE, et al. Body dissatisfaction in women across the lifespan: Results of the UNC-SELF and gender and body image (GABI) studies. EUROPEAN EATING DISORDERS REVIEW. 2013;21(1):52-59. doi:10.1002/erv.2201
• Gagne DA, Von Holle A, Brownley KA, et al. Eating disorder symptoms and weight and shape concerns in a large web-based convenience sample of women ages 50 and above: Results of the gender and body image (GABI) study. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2012;45(7):832-844. doi:10.1002/eat.22030
• Ulman TF, Von Holle A, Torgersen L, Stoltenberg C, Reichborn-Kjennerud T, Bulik CM. Sleep disturbances and binge eating disorder symptoms during and after pregnancy. SLEEP. 2012;35(10):1403-1411. doi:10.5665/sleep.2124
• Zerwas S, Von Holle A, Bulik CM. Childhood anxiety trajectories predict disordered eating in adolescence. JOURNAL OF WOMENS HEALTH. 2012;21(10):1008.
• Zerwas S, Von Holle A, Torgersen L, Reichborn-Kjennerud T, Stoltenberg C, Bulik CM. Maternal eating disorders and infant temperament: Findings from the norwegian mother and child cohort study. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2012;45(4):546-555. doi:10.1002/eat.20983
• Unikel C, Von Holle A, Bulik CM, Ocampo R. Disordered eating and suicidal intent: The role of thin ideal internalisation, shame and family criticism. EUROPEAN EATING DISORDERS REVIEW. 2012;20(1):39-48. doi:10.1002/erv.1070
• Siega-Riz AM, Von Holle A, Haugen M, et al. Gestational weight gain of women with eating disorders in the norwegian pregnancy cohort. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2011;44(5):428-434. doi:10.1002/eat.20835
• Reyes-Rodriguez ML, Von Holle A, Ulman TF, et al. Posttraumatic stress disorder in anorexia nervosa. PSYCHOSOMATIC MEDICINE. 2011;73(6):491-497. doi:10.1097/PSY.0b013e31822232bb
• Meltzer-Brody S, Zerwas S, Leserman J, Von Holle A, Regis T, Bulik C. Eating disorders and trauma history in women with perinatal depression. JOURNAL OF WOMENS HEALTH. 2011;20(6):863-870. doi:10.1089/jwh.2010.2360
• Dellava JE, Von Holle A, Torgersen L, et al. Dietary supplement use immediately before and during pregnancy in norwegian women with eating disorders. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2011;44(4):325-332. doi:10.1002/eat.20831
• Zucker N, Von Holle A, Thornton LM, et al. The significance of repetitive hair-pulling behaviors in eating disorders. JOURNAL OF CLINICAL PSYCHOLOGY. 2011;67(4):391-403. doi:10.1002/jclp.20770
• Berg CK, Torgersen L, Von Holle A, Hamer RM, Bulik CM, Reichborn-Kjennerud T. Factors associated with binge eating disorder in pregnancy. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2011;44(2):124-133. doi:10.1002/eat.20797
• Unikel C, Root T, Vonholle A, Ocampo R, Bulik CM. Disordered eating and substance use among a female sample of mexican adolescents. SUBSTANCE USE & MISUSE. 2011;46(4):523-534. doi:10.3109/10826081003725260
• Reyes-Rodriguez ML, Sala M, Von Holle A, et al. A description of disordered eating behaviors in latino males. JOURNAL OF AMERICAN COLLEGE HEALTH. 2011;59(4):266-272. doi:10.1080/07448481.2010.502205
• Bulik CM, Hoffman ER, Von Holle A, Torgersen L, Stoltenberg C, Reichborn-Kjennerud T. Unplanned pregnancy in women with anorexia nervosa. OBSTETRICS AND GYNECOLOGY. 2010;116(5):1136-1140. doi:10.1097/AOG.0b013e3181f7efdc
• Torgersen L, Ystrom E, Haugen M, et al. Breastfeeding practice in mothers with eating disorders. MATERNAL AND CHILD NUTRITION. 2010;6(3):243-252. doi:10.1111/j.1740-8709.2009.00208.x
• Reyes-Rodriguez ML, Franko DL, Matos-Lamourt A, et al. Eating disorder symptomatology: Prevalence among latino college freshmen students. JOURNAL OF CLINICAL PSYCHOLOGY. 2010;66(6):666-679. doi:10.1002/jclp.20684
• Kronenfeld LW, Reba-Harrelson L, Von Holle A, Reyes ML, Bulik CM. Ethnic and racial differences in body size perception and satisfaction. BODY IMAGE. 2010;7(2):131-136. doi:10.1016/j.bodyim.2009.11.002
• Reba-Harrelson L, Von Holle A, Hamer RM, Torgersen L, Reichborn-Kjennerud T, Bulik CM. Patterns of maternal feeding and child eating associated with eating disorders in the Norwegian Mother and Child Cohort Study (MoBa). EATING BEHAVIORS. 2010;11(1):54-61. doi:10.1016/j.eatbeh.2009.09.004
• Reba-Harrelson L, Von Holle A, Hamer RM, Swann R, Reyes ML, Bulik CM. Patterns and prevalence of disordered eating and weight control behaviors in women ages 25-45. EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY. 2009;14(4):E190-E198.
• Swann RA, Von Holle A, Torgersen L, Gendall K, Reichborn-Kjennerud T, Bulik CM. Attitudes toward weight gain during pregnancy: Results from the norwegian mother and child cohort study (MoBa). INTERNATIONAL JOURNAL OF EATING DISORDERS. 2009;42(5):394-401. doi:10.1002/eat.20632
• Bulik CM, Hamer RM, Crosby R, Root TL, Von Holle A, Thornton L. International journal of eating disorders: Statistical formatting requirements and reporting guidelines. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2009;42(3):193-194. doi:10.1002/eat.20677
• Bulik CM, Von Holle A, Siega-Riz AM, et al. Birth outcomes in women with eating disorders in the norwegian mother and child cohort study (MoBa). INTERNATIONAL JOURNAL OF EATING DISORDERS. 2009;42(1):9-18. doi:10.1002/eat.20578
• Bulik CM, Torgersen L, Reichborn-Kjennerud T, Gendall K, Von Holle A. The surgical management of intractable postpartum hemorrhage. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2009;88(4):489. doi:10.1080/00016340902777533
• Torgersen L, Von Holle A, Reichborn-Kjennerud T, et al. Nausea and vomiting of pregnancy in women with bulimia nervosa and eating disorders not otherwise specified. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2008;41(8):722-727. doi:10.1002/eat.20564
• Siega-Riz AM, Haugen M, Meltzer HM, et al. Nutrient and food group intakes of women with and without bulimia nervosa and binge eating disorder during pregnancy. AMERICAN JOURNAL OF CLINICAL NUTRITION. 2008;87(5):1346-1355.
• Crisafulli MA, Von Holle A, Bulik CM. Attitudes towards anorexia nervosa: The impact of framing on blame and stigma. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2008;41(4):333-339. doi:10.1002/eat.20507
• Berg CK, Bulik CM, Von Holle A, et al. Psychosocial factors associated with broadly defined bulimia nervosa during early pregnancy: findings from the Norwegian mother and child cohort study. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY. 2008;42(5):396-404.
• Von Holle A, Pinheiro AP, Thornton LM, et al. Temporal patterns of recovery across eating disorder subtypes. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY. 2008;42(2):108-117. doi:10.1080/00048670701787610
• Bulik CM, Von Holle A, Gendall K, et al. Maternal eating disorders influence sex ratio at birth. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2008;87(9):979-981. doi:10.1080/00016340802334385
• Bulik CM, Von Holle A, Hamer R, et al. Patterns of remission, continuation and incidence of broadly defined eating disorders during early pregnancy in the Norwegian Mother and Child Cohort Study (MoBa). PSYCHOLOGICAL MEDICINE. 2007;37(8):1109-1118. doi:10.1017/S0033291707000724
• Pinheiro AP, Thornton LM, Plotonicov KH, et al. Patterns of menstrual disturbance in eating disorders. INTERNATIONAL JOURNAL OF EATING DISORDERS. 2007;40(5):424-434. doi:10.1002/eat.20388

National Institute of Environmental Health Sciences

Postdoctoral activities

Research Triangle Park, NC

N/A

• Planned and co-lead the “Mentoring of Junior Faculties and Fellows” 1-hour session for branch retreat (October 2019)
• Guest lecturer for 2-hour short course, “Introduction to Statistics and Experimental Design” (January 2020)

University of North Carolina, Chapel Hill

N/A

Chapel Hill, NC

N/A

• Teaching Assistant, Advanced Epidemiologic Methods (Spring 2016)
• Guest lecturer, CEED postdoctoral yearly seminar series: “Statistical Analysis Plans in Research” (2008-2012)

Society of Epidemiologic Research

“Polygenic Risk Scores: challenges and opportunities for population health equity” symposium co-chair

Virtual conference

December 2020

National Institute of Environmental Health Sciences

Postdoctoral activities

Research Triangle Park, NC

2019 - 2020

• Trainee Assembly Steering Committee Member: Participated in the Innovative Research Award committee, planned a trainee career lunch discussion, participated in monthly meetings (2020)
• Summer Intern Poster Judge (July 2019)

National Institutes of Health Special Emphasis Panel/Scientific Review Group

Guest/substitute member

Bethesda, MD

2011

• ZMH1 ERB-D (02), HIV Prevention in MSM (May 2011)
• Interventions Committee for Adult Disorders (ITVA) (October 2011)

National Institute of Environmental Health Sciences

Postdoctoral training

Research Triangle Park, NC

2018 - 2019

• ‘Writing from the Reader’s Perspective’ 1-day workshop (November 2018)
• ‘Write Winning NIH Grant Proposals’ 1-day workshop (February 2019)
• ‘Scientists Teaching Science’, a 9-week pedagogy course (Spring 2019)
• Research Mentor Training (May 2019)

Society of Epidemiologic Research

N/A

N/A

2013-2020

American Heart Association

N/A

N/A

2015-2020

American Associaton for Cancer Research

N/A

N/A

2020